资源类型

期刊论文 20

年份

2024 1

2023 3

2022 7

2020 2

2018 1

2017 2

2015 1

2012 1

2000 1

展开 ︾

关键词

肝移植 2

3D打印 1

3D生物打印 1

CAR设计 1

HuMiX 1

他克莫司 1

代谢组学 1

免疫学 1

免疫细胞 1

免疫耐受 1

再生组织/器官 1

医学模具 1

可降解材料 1

器官短缺 1

器官移植 1

器官芯片 1

固有免疫细胞 1

基因编辑 1

复发 1

展开 ︾

检索范围：

排序： 展示方式：

A literature review of perishable medical resource management

《工程管理前沿（英文）》   页码 710-726 doi: 10.1007/s42524-023-0278-9

摘要： In recent decades, healthcare providers have faced mounting pressure to effectively manage highly perishable and limited medical resources. This article offers a comprehensive review of supply chain management pertaining to such resources, which include transplantable organs and healthcare products. The review encompasses 93 publications from 1990 to 2022, illustrating a discernible upward trajectory in annual publications. The surveyed literature is categorized into three levels: Strategic, tactical, and operational. Key problem attributes and methodologies are analyzed through the assessment of pertinent publications for each problem level. Furthermore, research on service innovation, decision analytics, and supply chain resilience elucidates potential areas for future research.

关键词： perishable medical resources     organ transplant     healthcare products     decision analytics     operations management    

HTML PDF 收藏

免疫细胞在器官移植免疫排斥和免疫耐受中的不同作用 Review

干晓杰, 古鉴, 鞠峥, 吕凌

《工程（英文）》 2022年 第10卷 第3期   页码 44-56 doi: 10.1016/j.eng.2021.03.029

摘要：

器官移植免疫排斥反应是由多种细胞参与的复杂的免疫应答过程，是决定移植成败和患者生存的关键因素。目前大多数器官移植患者采用免疫抑制剂和生物制剂的组合疗法来控制移植器官的免疫排斥反应，然而免疫抑制剂的使用会降低移植患者免疫系统功能，导致严重的并发症，如慢性感染、恶性肿瘤等。因
此，彻底了解器官移植免疫耐受和免疫排斥的相关机制对于开发更好的治疗方案和改善患者预后至关重要。本文对免疫细胞在器官移植免疫排斥和免疫耐受诱导过程中的作用，以及目前针对移植患者处于临床试验阶段的新型细胞治疗进行概述。

关键词： 免疫细胞     固有免疫细胞     适应性免疫细胞     器官移植     免疫耐受    

HTML PDF 收藏

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

《医学前沿（英文）》 2023年 第17卷 第3期   页码 527-533 doi: 10.1007/s11684-022-0967-5

摘要： In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation (TR), taking into account its dynamic nature, after biatrial orthotopic heart transplant (OHT). All consecutive adult patients undergoing biatrial OHT (1984−2017) with an available follow-up echocardiogram were included. Mixed-models were used to model the evolution of TR. The mixed-model was inserted into a Cox model in order to address the association of the dynamic TR with mortality. In total, 572 patients were included (median age: 50 years, males: 74.9%). Approximately 32% of patients had moderate-to-severe TR immediately after surgery. However, this declined to 11% on 5 years and 9% on 10 years after surgery, adjusted for survival bias. Pre-implant mechanical support was associated with less TR during follow-up, whereas concurrent LV dysfunction was significantly associated with more TR during follow-up. Survival at 1, 5, 10, 20 years was 97% ± 1%, 88% ± 1%, 66% ± 2% and 23% ± 2%, respectively. The presence of moderate-to-severe TR during follow-up was associated with higher mortality (HR: 1.07, 95% CI (1.02–1.12), p = 0.006). The course of TR was positively correlated with the course of creatinine (R = 0.45). TR during follow-up is significantly associated with higher mortality and worse renal function. Nevertheless, probability of TR is the highest immediately after OHT and decreases thereafter. Therefore, it may be reasonable to refrain from surgical intervention for TR during earlier phase after OHT.

关键词： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

HTML PDF 收藏

用于器官芯片的工程化血管系统 Review

Abdellah Aazmi, 周竑钊, 李雨亭, 俞梦飞, 许晓斌, 吴钰桐, 马梁, 张斌, 杨华勇

《工程（英文）》 2022年 第9卷 第2期   页码 131-147 doi: 10.1016/j.eng.2021.06.020

摘要：

器官芯片技术是一种很有前途的三维（3D）动态培养方法，可确保准确高效的细胞培养，在临床前试验中具有替代动物模型的巨大潜力。血管系统是人体内最丰富的器官，在氧气交换和物质传递中起着至关重要的作用，是组织器官生存的决定性因素。因此，必须将血管系统集成到器官芯片中，以重建组织和器官微环境及其生理功能。本文讨论了血管与新兴器官芯片技术之间的协同作用，为复现生理学和疾病特征提供了更好的可能性。此外，回顾了血管化的器官芯片制造过程的不同步骤，包括使用不同生物制造策略的结构制造和组织构建。最后，概述了这项技术在器官和肿瘤培养这个有极具吸引力且快速发展的领域的适用性。

关键词： 器官芯片     血管     生物打印     肿瘤芯片    

HTML PDF 收藏

Piezoelectric pump with flexible venous valves for active cell transmission

《机械工程前沿（英文）》 2022年 第17卷 第4期 doi: 10.1007/s11465-022-0712-4

摘要： The development of organ-on-a-chip systems demands high requirements for adequate micro-pump performance, which needs excellent performance and effective transport of active cells. In this study, we designed a piezoelectric pump with a flexible venous valve inspired by that of humans. Performance test of the proposed pump with deionized water as the transmission medium shows a maximum output flow rate of 14.95 mL/min when the input voltage is 100 V, and the pump can transfer aqueous solutions of glycerol with a viscosity of 10.8 mPa·s. Cell survival rate can reach 97.22% with a yeast cell culture solution as the transmission medium. A computational model of the electric-solid-liquid multi-physical field coupling of the piezoelectric pump with a flexible venous valve is established, and simulation results are consistent with experimental results. The proposed pump can help to construct the circulating organ-on-a-chip system, and the simple structure and portable application can enrich the design of microfluidic systems. In addition, the multi-physical field coupling computational model established for the proposed piezoelectric pump can provide an in-depth study of the characteristics of the flow field, facilitating the optimal design of the micro-pump and providing a reference for the further study of active cell transport in organ-on-a-chip systems.

关键词： venous valve     flexible venous valve     cell transmission     organ-on-a-chip system     piezoelectric device    

HTML PDF 收藏

肝脏移植术后糖尿病患者肠道微生物组的变化 Article

凌琪, 韩玉秋, 马越, 王晓森, 朱铮, 王靖宇, 曹佳莹, 林笑含, 王军, 王保红

《工程（英文）》 2023年 第31卷 第12期   页码 98-111 doi: 10.1016/j.eng.2023.09.006

摘要：

移植后糖尿病（PTDM）会增加肝移植（LT）受者移植失败和死亡的风险。实验研究表明免疫抑制性他克莫司（TAC）介导的肠道生态失调可能导致血糖紊乱，但仍尚未见相关临床研究报道。 因此，本研究通过高通量鸟枪法宏基因组测序和代谢组学分析相结合的方法，对PTDM和非PTDM的肝脏移植受者队列中的肠道微生物组（IM）进行了表征，并破译了IM、TAC剂量和PTDM之间的潜在关联。 通过与非 PTDM 和经典II型糖尿病（T2DM）进行对比分析，确定了PTDM患者的肠道微生物组代表性特征为：变形菌门富集和拟杆菌门减少。有趣的是，与改变的微生物代谢产物相一致，这些微生物在PTDM患者中的丰都变化与TAC的剂量显著关联。 具体来说，与低TAC 谷浓度（< 5 ng∙mL–1） 的移植受体相比较，高 TAC 谷浓度（> 5 ng∙mL–1）移植受者中的有益微生物水平被显著降低；同时，通过检测粪便代谢物发现其中参与α-亚麻酸和花生四烯酸-这些降低糖尿病发生的有益代谢物的显著降低。更进一步，这些微生物标签分子的变化与移植受者的血糖紊乱程度显著有关。 总之，PTDM患者的粪便微生物组和代谢组发生了显著变化，且与 TAC 剂量相关。 这项研究是首个探索PTDM患者的细菌分类学组成变化和细菌基因功能变化，以更好地理解IM对PTDM的影响。

关键词： 移植后糖尿病     他克莫司     红基因组学     代谢组学    

HTML PDF 收藏

Emerging roles of podoplanin in vascular development and homeostasis

null

《医学前沿（英文）》 2015年 第9卷 第4期   页码 421-430 doi: 10.1007/s11684-015-0424-9

摘要：

Podoplanin (PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Prox1 and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.

关键词： podoplanin     CLEC-2     Prox1     O-glycosylation     lymphatic vascular development and maintenance     lymphoid organ homeostasis    

HTML PDF 收藏

关于3D打印技术在医学模具以及再生组织和器官方面的应用综述

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

《工程（英文）》 2017年 第3卷 第5期   页码 653-662 doi: 10.1016/J.ENG.2017.05.013

摘要：

医学模型或模具已广泛应用于医学培训和医患互动领域，同时也日益应用于手术规划、医学计算模型、算法核实和验证以及医疗器械的开发等方面。这种新应用需要高保真度、患者特异性及模拟组织结构的医学模具，其不仅能够模拟人体器官的几何结构，而且还具有器官的功能。随着三维（3D）打印和3D 生物打印技术的快速发展，许多研究人员已经开始使用增材制造技术来生产具有多种功能的医学模具。本文综述了3D 打印和3D 生物打印技术在制作功能性医学模具和生物结构方面的应用。特别讨论了3D 打印功能性医学模具（即组织模拟医学模具、放射性医学模具和生理医学模具）及被用于再生组织和器官的3D 生物打印模具的制备（即混合模式支架材料、可转换支架和集成传感器）工艺、发展现状以及未来发展趋势。

关键词： 3D打印     3D生物打印     医学模具     再生组织/器官     支架    

HTML PDF 收藏

A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 381-387 doi: 10.1007/s11684-012-0229-z

摘要：

Application of volatile anesthetics greatly alters modern medicine. There are obvious advantages of volatile anesthetics such as strong anesthetic potency, rapid onset and elimination through respiration system. Isoflurane is one of the most widely used volatile anesthetics in clinic. Emulsified isoflurane, the emulsion of isoflurane, is a novel intravenous general anesthetic. With the development of emulsified isoflurane in the past fifteen years, its utility has spread from intravenous general anesthesia to various fields including regional anesthesia, organ protection, as well as anesthetic pharmacological study. In this review, we will summarize literatures of emulsified isoflurane about its history, clinical application and future potential utility in the above mentioned fields.

关键词： emulsified isoflurane (EI)     general anesthesia     regional anesthesia     organ protection     anesthetic pharmacological study    

HTML PDF 收藏

State-of-the-art of intelligent minimally invasive surgical robots

Masakatsu G. Fujie, Bo Zhang

《医学前沿（英文）》 2020年 第14卷 第4期   页码 404-416 doi: 10.1007/s11684-020-0743-3

摘要： A number of developed countries are rapidly turning into super-aged societies. Consequently, the demand for reduced surgical invasiveness and enhanced efficiency in the medical field has increased due to the need to reduce the physical burden on older patients and shorten their recovery period. Intelligent surgical robot systems offer high precision, high safety, and reduced invasiveness. This paper presents a review of current intelligent surgical robot systems. The history of robots and three types of intelligent surgical robots are discussed. The problems with current surgical robot systems are then analyzed. Several aspects that should be considered in designing new surgical systems are discussed in detail. The paper ends with a summary of the work and a discussion of future prospects for surgical robot development.

关键词： robot history     medical robot     surgical robot     radiofrequency ablation     organ model    

HTML PDF 收藏

Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

《医学前沿（英文）》 2020年 第14卷 第2期   页码 232-248 doi: 10.1007/s11684-020-0774-9

摘要： Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, gastrointestinal dysfunction, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. To improve the cure rate and reduce the mortality of patients with severe- and critical-type COVID-19, this paper summarizes the experience of organ function support in patients with severe- and critical-type COVID-19 in Optical Valley Branch of Tongji Hospital, Wuhan, China. This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems, including respiratory, circulatory, renal, gastrointestinal, hepatic, and hematological systems, among patients with severe- and critical-type COVID-19. This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.

关键词： COVID-19     severe and critical type     organ function support    

HTML PDF 收藏

Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

《医学前沿（英文）》 2018年 第12卷 第5期   页码 572-579 doi: 10.1007/s11684-017-0561-4

摘要：

The dimension of the levator hiatus is a possible predictor of pelvic organ prolapse (POP). This retrospective study investigated 360 women who went to urogynecological clinic for pelvic floor discomfort. Levator hiatus dimensions were obtained by three-dimensional transperineal ultrasound and results were compared between women with and without significantly objective prolapse (International Continence Society POP quantification, grade 2 or higher). Receiver operating characteristic (ROC) curve analyses were performed to determine valid screening index for detecting abnormal levator hiatus distensibility. Women with significantly objective prolapse had significantly higher levator hiatus dimensions than those without (all P <0.001). ROC curve analyses confirmed that hiatal area (HA) of 19.5 cm2 during Valsalva maneuver can be used as single-screening index for abnormal levator hiatus distensibility with sensitivity of 0.80 and specificity of 0.70. In this study, we used a two-step method and achieved higher sensibility (0.80 vs. 0.87) without reducing specificity (0.70 vs. 0.71) compared with a single-screening index method. As a result, we suggest that HA≥19.5 cm2 during Valsalva maneuver is an indicator of abnormal levator hiatus distensibility in Chinese women and that the two-step method has higher sensitivity in detecting abnormal distensibility.

关键词： three-dimensional transperineal ultrasound     levator hiatus     levator ani muscle     pelvic organ prolapse    

HTML PDF 收藏

Legacies and health risks of heavy metals, polybrominated diphenyl ethers, and polychlorinated dibenzo-dioxins/furans at e-waste recycling sites in South China

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1679-z

摘要：

● Heavy metals and organic toxins may persist in legacy sites for a long time.

关键词： E-waste     Human health risk     Organ risk     Heavy metal toxicity     PBDE     PCDD/F    

HTML PDF 收藏

肝内区域免疫对肝移植后肿瘤复发的影响 Review

刘江, 卢宠茂, 万钧

《工程（英文）》 2022年 第10卷 第3期   页码 57-64 doi: 10.1016/j.eng.2021.11.012

摘要：

肝脏恶性肿瘤是肝移植的一个主要适应症，但是肝移植后肿瘤复发却是影响受体长期生存的一个严峻临床挑战。肿瘤生物学特征、分期和移植后的免疫抑制状态一直被认为是肝癌复发的危险因素。而越来越多的证据表明，肝脏缺血再灌注（IR）对同种异体移植物的损伤则为肝移植后的肿瘤细胞侵袭性、转移性
提供了有利的免疫微环境。在活体肝移植中，边缘移植物（如小体积或脂肪移植物）的严重损伤与较低的无复发生存率之间的相关性，证实了IR 损伤与肿瘤复发之间的关联。IR 可引起肝内免疫微环境重构，包括恶化移植物损伤的促炎反应和加快组织修复的抗炎反应。然而，肝内区域免疫对移植后肿瘤复发的作
用尚不清晰。本文详述了IR 损伤诱导的肝内体液微环境和调节性区域免疫微环境，以及它们如何影响肝移植后肿瘤复发的最新研究进展。综合理解移植后肝内区域免疫，将为移植后肿瘤复发提供精准诊断、治疗和预后预测的新策略。

关键词： 肝移植     肝癌     复发     免疫学    

HTML PDF 收藏

组织工程学——现代生物生命科学的前沿

张涤生

《中国工程科学》 2000年 第2卷 第10期   页码 21-25

摘要：

组织工程是应用细胞生物学和工程学的原理研究和开发，以达到修复和重建损伤的组织或器官的外形和功能的生物替代物的一门新学科，是继细胞生物学和分子生物学后，人类生命科学发展史上又一新的里程碑，标志着医学将超越组织和器官移植的旧模式，进人制造组织和器官的新时代，将在21世纪中绽露头角。

文章简略介绍世界组织工程发展历史及各类组织和器官组织工程的研究现状，并介绍我国组织工程科研工作开展的最新情况。目前组织工程已有了迅猛发展，在不少方面已取得重大突破。由于其孕育的巨大科学价值_及广阔的研究和应用前景，因此加快我国组织工程的研究，尽早地投人临床应用，对我国医学科学事业和国民经济的发展具有重大意义。

关键词： 组织工程     可降解材料     组织器官重建     种子细胞    

HTML PDF 收藏

标题 作者 时间 类型 操作

A literature review of perishable medical resource management

期刊论文

免疫细胞在器官移植免疫排斥和免疫耐受中的不同作用

干晓杰, 古鉴, 鞠峥, 吕凌

期刊论文

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

期刊论文

用于器官芯片的工程化血管系统

Abdellah Aazmi, 周竑钊, 李雨亭, 俞梦飞, 许晓斌, 吴钰桐, 马梁, 张斌, 杨华勇

期刊论文

Piezoelectric pump with flexible venous valves for active cell transmission

期刊论文

肝脏移植术后糖尿病患者肠道微生物组的变化

凌琪, 韩玉秋, 马越, 王晓森, 朱铮, 王靖宇, 曹佳莹, 林笑含, 王军, 王保红

期刊论文

Emerging roles of podoplanin in vascular development and homeostasis

null

期刊论文

关于3D打印技术在医学模具以及再生组织和器官方面的应用综述

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

期刊论文

A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

null

期刊论文

State-of-the-art of intelligent minimally invasive surgical robots

Masakatsu G. Fujie, Bo Zhang

期刊论文

Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

期刊论文

Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

期刊论文

Legacies and health risks of heavy metals, polybrominated diphenyl ethers, and polychlorinated dibenzo-dioxins/furans at e-waste recycling sites in South China

期刊论文

肝内区域免疫对肝移植后肿瘤复发的影响

刘江, 卢宠茂, 万钧

期刊论文

组织工程学——现代生物生命科学的前沿

张涤生

期刊论文